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Kulkosky

Joseph Kulkosky, Ph.D.

Associate Professor of Biology
Chair of the Biology Department

Office Location:  St. Joseph Hall, Room 522
Office Phone:  215.248.7157
E-Mail:  kulkoskyj@chc.edu




Educational Background 

  • Ph.D., University of Pittsburgh
  • B.S., University of Scranton
  • Scholar of the American Foundation for AIDS Research (amFAR) 1991-1994

Previous Positions 

  • Postdoctoral Fellow: Cornell Medical Center
  • Fox Chase Cancer Center
  • Assistant Professor of Medicine: Thomas Jefferson University

Research Specialty 

  • AIDS Research - studying the mechanism of HIV-1 DNA integration and molecular strategies to eradicate HIV-1 latent reservoirs.

Recent Publications (of a total of 30 publications)

  • Kulkosky, J.,BouHamdan, M., Geist, A., Nunnari, G., Phinney, D.G., and R.J. Pomerantz. Pathogenesis of HIV-1 infection in bone marrow cells. Leukemia and Lymphoma, 37: 497-515, 2000.
  • BouHamdan, M., Kulkosky, J., Duan, L-X, and R.J. Pomerantz. Inhibition of HIV-1 replication and Infectivity by expression of a fusion protein, Vpr-anti-integrase single chain variable fragment (SFv): Intravirion molecular therapies. Journal of Human Virology 3: 6-15, 2000.
  • Kulkosky, J.,Culnan, D., Roman, J., Dornadula, G., Schnell, M., Boyd, M. and R.J. Pomerantz. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98: 3006-3015, 2001.
  • Patel, C.A., Muktar, M. Harley, S., Kulkosky, J., and R.J. Pomerantz. Lentiviral expression of HIV-1 Vpr induces apoptosis in human neurons. Journal of Neurovirology 8: 86-99, 2002.
  • Kulkosky, J.and R.J. Pomerantz. Approaching eradication of highly active anti-retroviral therapy persistent human immunodeficiency virus type 1 reservoirs with immune activation therapy. Clinical Infectious Diseases 35: 1520-1526, 2002.
  • Kulkosky, J., Nunnari, G., Otero, M., Calarota, S., Dornadula, G., Zhang, H., Sullivan, J., Xu, Y., De Simone, J., Babinchak, T., Stern, J., Cavert, W., Haase, A. and R.J. Pomerantz. Intensification and stimulation therapy for HIV-1 reservoirs in infected individuals on virally-suppressive HAART. J. of Infectious Diseases. 186: 1403-1411, 2002
  • DiMascio, M., Dornadula, G., Zhang, H., Sullivan, J., Xu, Y., Kulkosky, J., Pomerantz, R.J., and A.S. Perelson. In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to 5 copies per milliliter, with a half-life of 6 months. Journal of Virology 77: 2271-2275, 2003.
  • Kulkosky, J., J. Sullivan, Y. Xu, A. Malin-Markham, M. Otero, S. Calarota, J. Zielinski, D. Culnan and R.J. Pomerantz. Genotypic alteration of HAART-persistent reservoirs in vivo. Virology, in press, 2003.

  • Feng-Xiang Wang, Y. Xu, J. Sullivan, E. Souder, E. Argyris, E. A. Acheampong, J. Fisher, M Sierra, M.M. Thomson, R. Najera, I. Frank, J. Kulkosky, R.J. Pomerantz and G. Nunnari. IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J. Clinical Investigation. 115:128-137, 2005. 

  • Nunnari, G., D. Leto, J. Sullivan, Y. Xu, K. Mehlman, J. Kulkosky and R.J. Pomerantz. Seminal Reservoirs during an HIV-1 Eradication Trial. AIDS. 16:39-45, 2005. 
  • Nunnari, G., Sullivan, J., Xu, Y., Nyirjesy, P., Kulkosky, J., Cavert, W., Frank, I., and R.J. Pomerantz. HIV type 1 cervicovaginal reservoirs in the era of HAART. AIDS Research and Human Retroviruses. 21:714-718. 2005 
  • Kulkosky, J and S. Bray. HAART-Persistent HIV-1 Latent Reservoirs: Their Origin, Mechanisms of Stability and Potential Strategies for Eradication. Current HIV Research. 4:199-208. 2006. 
  • Katz, R., Jack-Scott, E., Narezkina, A., Palagin, I., Boimel, P., Kulkosky, J., Nicolas, E., Greger, J.G., and A.M. Skalka. High Frequency Epigenetic Repression and silencing of Retroviruses can be antagonized  by HDAC inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. Journal of Virology. 2007 
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