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Kenneth J. Soprano, Ph.D.
Vice President for Academic Affairs
Dean of the Faculty
Office Location: St. Joseph Hall, Third Floor, Room 80
Office Phone: 215.248.7022
E-Mail: sopranok@chc.edu
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Educational Background
- A.B. Biology, College of the Holy Cross, 1974
- M.S. Microbiology, NJ, 1976
- Ph.D. Microbiology, NJ, 1978
Administrative Responsibilities
- Chief Academic Officer of the College
- Exercises leadership in the areas of undergraduate, graduate and continuing education programs, curriculum development and assessment, faculty development, enrollment management, academic budgets and faculty recruitment.
Honors, Awards, Organizational Affiliations
- Recipient, Christian R. and Mary P. Lindback Foundation Award for Distinguished Teaching
- Member, Editorial Board, Molecular Biology Reports
- Member, Editorial Board, Journal of Cellular Biochemistry
- Member, Editorial Board, Journal of Experimental & Clinical Cancer Research
- Contributing Editor, The Women’s Oncology Review
- Member, NIH/NCI Basic Mechanisms of Cancer Therapeutics (BMCT) Study Section
- Past Member, Medical and Biological Technical Advisory Council of Southeastern PA.
- Past Member, Research Advisory Council, Ben Technology Center Past Member, Board of Directors
- Past Member, NCI Insight Awards to Stamp Out Breast Cancer
- Past Member, DOD Ovarian Cancer Research Program Scientific Peer Review Committee
- Past Chair, DOD Ovarian Cancer Research Program Scientific Peer Review Committee
Recent Publications
Radu M, Soprano KJ, S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines. J Cell Physiol 2008 (in press)
Fields AL, Soprano KJ, Characterization of alterations of Rb2/p130 tumor suppressor in all-trans-retinoic acid resistant SK-OV3 ovarian carcinoma cells. J Cell Physiol 217:1(77-85)2008
Vucetic Z, Zhang Z, Zhao J, Wang F, Soprano KJ, Soprano DR, Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs. Mol Cell Biol 28:8(2549-58)2008
Ravikumar S, Perez-Liz G, Del Vale L, Soprano KJ, Insulin receptor substrate-1 is an important mediator of ovarian cancer cell growth suppression by all-trans retinoic acid. Cancer Res 67:19(9266-75)2007 1
Fields AL, Soprano KJ, Retinoids in biological control and cancer. J Cell Biochem 102:4(886-98)2007
Jiang T, Soprano DR, Soprano KJ, GADD45A is a mediator of CD437 induced apoptosis in ovarian carcinoma cells. J Cell Physiol 212:3(771-9)2007
Soprano DR, Teets BW, Soprano KJ, Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells. Vitam Horm 75:(69-95)2007
Buletic Z, Soprano KJ, Soprano DR, Retinoid targets for the treatment of cancer. Crit Rev Eukaryot Gene Expr 16:3(193-210)2006
Soprano KJ, Purev E, Vuocolo S, Soprano DR, Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. Oncogene 25:38(5315-25)2006
Purev E, Giordano A, Soprano DR, Soprano KJ, Interaction of PP2A catalytic subunit with Rb2/p130 is required for all-trans retinoic acid suppression of ovarian carcinoma cell growth. J Cell Physiol 206:2(495-502)2006
Ramírez CJ, Haberbusch JM, Soprano KJ, Retinoic acid induced repression of AP-1 activity is mediated by protein phosphatase 2A in ovarian carcinoma cells. J Cell Biochem 96:1(170-82)2005
Purev E, Soprano DR, Soprano KJ, Effect of all-trans retinoic acid on telomerase activity in ovarian cancer cells. J Exp Clin Cancer Res 23:2(309-16)2004
Soprano DR, Qin P, Soprano KJ, Retinoic acid receptors and cancers. Annu Rev Nutr 24:(201-21)2004
D'Andrilli G, Masciullo V, Bagella L, Tonini T, Minimo C, Zannoni GF, Giuntoli RL 2nd, Carlson JA Jr, Soprano DR, Soprano KJ, Scambia G, Giordano A, Frequent loss of pRb2/p130 in human ovarian carcinoma. Clin Cancer Res 10:9(3098-103)2004 May 1
Qin P, Haberbusch JM, Soprano KJ, Soprano DR, Retinoic acid regulates the expression of PBX1, PBX2, and PBX3 in P19 cells both transcriptionally and post-translationally. J Cell Biochem 92:1(147-63)2004
Holmes WF, Soprano KJ, Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines. J Cell Physiol 199:3(317-29)2004
Vuocolo S, Soprano DR, Soprano KJ, p27/Kip1 mediates retinoic acid-induced suppression of ovarian carcinoma cell growth. J Cell Physiol 199:2(237-43)2004
Qin P, Haberbusch JM, Zhang Z, Soprano KJ, Soprano DR, Pre-B cell leukemia transcription factor (PBX) proteins are important mediators for retinoic acid-dependent endodermal and neuronal differentiation of mouse embryonal carcinoma P19 cells. J Biol Chem 279:16(16263-71)2004
